1.

尋覓抗老藥丸
科學人8：72-78。撰文／連恩、殷格朗、羅斯　翻譯／黃榮棋

• 「吃得少」可能是青春永駐之道，但是有多少人真能清心寡欲，少食求壽？為了尋覓兩全其美的抗老藥丸，讓你既能抗老又能吃，科學家上窮碧落下黃泉……

2.

啟動長壽基因
科學人50：24-31。撰文／辛克萊（David A. Sinclair）、賈倫堤（Lenny Guarente）

• 老化不是必然的發育過程，而是身體組織器官逐漸衰敗而造成的。科學家發現，有一群對抗逆境的蛋白質Sirtuin，可以保護DNA、調節代謝作用、抑制發炎，而這些都與老化有關。
• 有一群特別的基因，在生物體處於艱困的時期，會協助身體的防衛，這群基因能夠增進個體的健康和壽命。如果想要延年益壽、減少老年病痛，關鍵就在於解開這群基因作用的奧秘。

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Hayflick limitation :
“Replicative senescence” results from an intrinsic natural barrier to cell division exhibited by all normal somatic cells.

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Telomere :
Eukaryotes deal with the end-replication issue by having expandable, noncoding sequences at the ends of their DNA.

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Telomerase :
An enzyme has a short molecular of RNA with a sequence that serves as a template for extending the 3’ end of the telomere.

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Free radicals :
They are atoms or groups of atoms with an odd (unpaired) number of electrons and can be formed when oxygen interacts with certain molecules.

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Free radical theory of aging :
Free radicals wreck havoc by damaging DNA mitochondria, altering biochemical compounds, corroding cell membranes and killing cells outright. The cumulative effects of free radicals also underlie the gradual deterioration that is the hallmark of aging in all individuals, healthy as well as sick.

6.

Cu/Zn SOD :
An enzyme catalyzes the proton-dependent dismutation of two superoxide radical anions to molecular oxygen and hydrogen peroxide.

7.

Superoxide Dismutase/Catalase Mimetics :
These compounds exhibit both SOD- and catalase-like activities.

8.

Caloric Restriction (CR) :
It is the practice of limiting dietary energy intake in the hope that it will improve health and slow the aging process.

9.

2-deoxyglucose :
A glucose analog which can interfere glycolysis results to ATP and free radicals decrease.

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